Effect of ornithine alpha ketoglutarate on disturbances of brain metabolism caused by high blood ammonia.
نویسندگان
چکیده
The administration of ammonium salts to free ventilated dogs causes an increase in the anaerobic consumption of glucose. Prior and simultaneous administration of the drug ornithine alpha ketoglutarate not only attenuates the rise in blood ammonia but also favourably affects these changes in brain metabolism.
منابع مشابه
Effect of Ornithine Alpha Ketoglutarate (OAKG) on the Response of Brain Metabolism to Hypoxia in the Dog
1. Michel H, Oge P, Bertrand L: Actionede Palpha ketoglutarate d'ornithine sur rhyperammoniemic du cirrhotique. Presse Med 79: 867-868, 1971 2. James IM, Hamlyn AN, Brant PC, Hildrew P: Effect of ornithine alpha oxoglutarate on brain metabolism in patients with chronic liver disease. J Neurol Neurosurg Psychiatry 37: 214-218, 1975 3. James IM, MacDonnell L, Xanalatos C: Effect of ammonium salts...
متن کاملEffect of ornithine alpha ketoglutarate (OAKG) on the response of brain metabolism to hypoxia in the dog.
Hypoxia is well known to cause an increase in brain anaerobic glycolysis. Ornithine alpha ketoglutarate (OAKG) given to six dogs was shown to attenuate these metabolic disturbances caused by hypoxia. Brain oxygen utilization was higher after ornithine alpha ketoglutarate during hypoxia than during a period of hypoxia alone. It is suggested that the clinical usefulness of OAKG should be explored...
متن کاملCoadministration of ornithine and alpha-ketoglutarate is no more effective than ornithine alone as an arginine precursor in piglets enterally fed an arginine-deficient diet.
Simultaneous administration of alpha-ketoglutarate and ornithine, in a 1:2 molar ratio, may improve the effectiveness of ornithine as an arginine precursor in neonatal piglets by shifting ornithine metabolism away from oxidation and toward the synthesis of arginine and other metabolically important compounds. To study this proposed mechanism, enterally fed piglets were allocated to receive 1 of...
متن کاملL-ornithine vs. L-ornithine-L-aspartate as a treatment for hyperammonemia-induced encephalopathy in rats.
BACKGROUND/AIMS The effect of L-ornithine (ORN) and L-ornithine-L-aspartate (OA) therapy on "extracerebral" nitrogen metabolism, brain metabolism and neurotransmission has been investigated in portacaval shunted rats with hyperammonemia-induced encephalopathy. METHODS One day before ammonium-acetate infusion, a portacaval shunt was performed in three experimental groups: 1-control rats, 2-ORN...
متن کاملPharmacological Study on L-ornithine L-aspartate.
塩屋 明利 ・倉石 弘一 ・柿本 守夫 ・玉真 洋子 In a healthy subject, ammonia produced in the body is excreted by the kidney in the form of urea, the product of the urea cycle (1), or converted into substances useful for the body. In cases of hepatic disorders, on the other hand, blood ammonia level is known to increase (2-6). It is likely that ammonia in high concentrations interferes with the TCA cycle (7) and th...
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ورودعنوان ژورنال:
- Gut
دوره 13 7 شماره
صفحات -
تاریخ انتشار 1972